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A complete SARS-CoV-2 and COVID-19 overview, Half 2: host extracellular to systemic results of SARS-CoV-2 an infection – European Journal of Human Genetics

  • Rydland HT, Friedman J, Stringhini S, Hyperlink BG, Eikemo TA. The radically unequal distribution of Covid-19 vaccinations: a predictable but avoidable symptom of the elemental causes of inequality. Humanit Soc Sci Commun. 2022;9:1–16.

  • Jalali N, Brustad HK, Frigessi A, MacDonald EA, Meijerink H, Feruglio SL, et al. Elevated family transmission and immune escape of the SARS-CoV-2 Omicron in comparison with Delta variants. Nat Commun. 2022;13:5706.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jamison DA Jr, Anand Narayanan S, Trovão NS, Guarnieri JW, Topper MJ, Moraes-Vieira PM, et al. A complete SARS-CoV-2 and COVID-19 overview, Half 1: Intracellular overdrive for SARS-CoV-2 an infection. Eur J Hum Genet. 2022;30:889–98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Prasad Okay, Khatoon F, Rashid S, Ali N, AlAsmari AF, Ahmed MZ, et al. Focusing on hub genes and pathways of innate immune response in COVID-19: a community biology perspective. Int J Biol Macromol. 2020;163:1–8.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Minakshi R, Padhan Okay, Rani M, Khan N, Ahmad F, Jameel S. The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the sort 1 interferon receptor. PLoS ONE. 2009;4:e8342.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, et al. Core mitochondrial genes are down-regulated throughout SARS-CoV-2 an infection of rodent and human hosts. Sci Transl Med. 2023;15:eabq1533.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shen B, Yi X, Solar Y, Bi X, Du J, Zhang C, et al. Proteomic and metabolomic characterization of COVID-19 affected person sera. Cell. 2020;182:59–72.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng ZJ, Yang X, Wang H. Hyperhomocysteinemia and endothelial dysfunction. Curr Hypertens Rev. 2009;5:158–65.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barberis E, Timo S, Amede E, Vanella VV, Puricelli C, Cappellano G, et al. Massive-scale plasma evaluation revealed new mechanisms and molecules related to the host response to SARS-CoV-2. Int J Mol Sci. 2020;21:8623.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, et al. Extreme SARS-CoV-2 an infection in people is outlined by a shift within the serum lipidome leading to dysregulation of eicosanoid immune mediators. J Immunol. 2021;206:329.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Thomas T, Stefanoni D, Reisz JA, Nemkov T, Bertolone L, Francis RO, et al. COVID-19 an infection alters kynurenine and fatty acid metabolism, correlating with IL-6 ranges and renal standing. JCI perception. 2020;5:e140327.

  • Tanner JE, Alfieri C. The fatty acid lipid metabolism nexus in COVID-19. Viruses. 2021;13:90.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, et al. A mechanistic mannequin and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. elife. 2020;9:e59177.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Clarke SA, Abbara A, Dhillo WS. Affect of COVID-19 on the endocrine system: a mini-review. Endocrinology. 2022;163:bqab203.

    Article 
    PubMed 

    Google Scholar
     

  • Lazartigues E, Qadir MM, Mauvais-Jarvis F. Endocrine significance of SARS-CoV-2’s reliance on ACE2. Endocrinology. 2020;161:bqaa108.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kitsou Okay, Kotanidou A, Paraskevis D, Karamitros T, Katzourakis A, Tedder R, et al. Upregulation of human endogenous retroviruses in bronchoalveolar lavage fluid of COVID-19 sufferers. Microbiol Spectr. 2021;9:e01260–21.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Alfaro E, Díaz-García E, García-Tovar S, Zamarrón E, Mangas A, Galera R, et al. Impaired kallikrein-kinin system in COVID-19 sufferers’ severity. Entrance Immunol. 2022;13:909342.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sur S, Steele R, Isbell TS, Ray R, Ray RB. Circulatory exosomes from COVID-19 sufferers set off NLRP3 inflammasome in endothelial cells. Mbio. 2022;13:e00951–22.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pesce E, Manfrini N, Cordiglieri C, Santi S, Bandera A, Gobbini A, et al. Exosomes recovered from the plasma of COVID-19 sufferers expose SARS-CoV-2 spike-derived fragments and contribute to the adaptive immune response. Entrance Immunol. 2022;12:785941.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ching KL, de Vries M, Gago J, Dancel-Manning Okay, Sall J, Rice WJ, et al. ACE2-containing defensosomes function decoys to inhibit SARS-CoV-2 an infection. PLoS Biol. 2022;20:e3001754.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Peluso MJ, Deeks SG, Mustapic M, Kapogiannis D, Henrich TJ, Lu S, et al. SARS‐CoV‐2 and mitochondrial proteins in neural‐derived exosomes of COVID‐19. Ann Neurol. 2022;91:772–81.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leitão AL, Enguita FJ. A structural view of miRNA biogenesis and performance. Noncoding RNA. 2022;8:10.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Farr RJ, Rootes CL, Rowntree LC, Nguyen TH, Hensen L, Kedzierski L, et al. Altered microRNA expression in COVID-19 sufferers permits identification of SARS-CoV-2 an infection. PLoS Pathog. 2021;17:e1009759.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, et al. Function of miR-2392 in driving SARS-CoV-2 an infection. Cell Rep. 2021;37:109839.

  • Panda M, Kalita E, Singh S, Kumar Okay, Rao A, Prajapati VK. MiRNA-SARS-CoV-2 dialogue and potential anti-COVID-19 therapies. Life Sci. 2022:120761.

  • Shaath H, Vishnubalaji R, Elkord E, Alajez NM. Single-cell transcriptome evaluation highlights a job for neutrophils and inflammatory macrophages within the pathogenesis of extreme COVID-19. Cells. 2020;9:2374.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mukherjee S, Banerjee B, Karasik D, Frenkel-Morgenstern M. mRNA-lncRNA Co-expression community evaluation reveals the function of lncRNAs in immune dysfunction throughout extreme SARS-CoV-2 an infection. Viruses. 2021;13:402.

    Article 
    CAS 

    Google Scholar
     

  • Devadoss D, Acharya A, Manevski M, Houserova D, Cioffi MD, Pandey Okay, et al. Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype. Iscience. 2022;25:104685.

  • Enguita FJ, Leitão AL, McDonald JT, Zaksas V, Das S, Galeano D, et al. The interaction between lncRNAs, RNA-binding proteins and viral genome throughout SARS-CoV-2 an infection reveals robust connections with regulatory occasions concerned in RNA metabolism and immune response. Theranostics. 2022;12:3946.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Sullivan KD, Galbraith MD, Kinning KT, Bartsch KW, Levinsky NC, Araya P, et al. The COVIDome explorer researcher portal. Cell Rep. 2021;36:109527.

  • Yang M, Qi M, Xu L, Huang P, Wang X, Solar J, et al. Differential host circRNA expression profiles in human lung epithelial cells contaminated with SARS-CoV-2. Infect, Genet Evol. 2021;93:104923.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wu Y, Zhao T, Deng R, Xia X, Li B, Wang X. A examine of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood. Sci Rep. 2021;11:7991.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Farshidfar F, Koleini N, Ardehali H. Cardiovascular problems of COVID-19. JCI perception. 2021;6:e148980.

  • Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. COVID-19 and heart problems. Circulation. 2020;141:1648–55.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Park J, Foox J, Hether T, Danko DC, Warren S, Kim Y, et al. System-wide transcriptome harm and tissue id loss in COVID-19 sufferers. Cell Rep. Med. 2022;3:100522.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner Okay, et al. Affiliation of cardiac an infection with SARS-CoV-2 in confirmed COVID-19 post-mortem instances. JAMA Cardiol. 2020;5:1281–5.

    Article 
    PubMed 

    Google Scholar
     

  • Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell an infection and endotheliitis in COVID-19. Lancet. 2020;395:1417–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, et al. Inhibition of SARS-CoV-2 infections in engineered human tissues utilizing clinical-grade soluble human ACE2. Cell. 2020;181:905–13.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Chang R, Mamun A, Dominic A, Le NT. SARS-CoV-2 mediated endothelial dysfunction: the potential function of persistent oxidative stress. Entrance Physiol. 2021;11:605908.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in extreme SARS-CoV-2 an infection. Crit Care. 2020;24:1–8.

    Article 

    Google Scholar
     

  • Tersalvi G, Vicenzi M, Calabretta D, Biasco L, Pedrazzini G, Winterton D. Elevated troponin in sufferers with coronavirus illness 2019: potential mechanisms. J Card Fail. 2020;26:470–5.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arcanjo A, Logullo J, Menezes CC, de Souza Carvalho Giangiarulo TC, Dos Reis MC, de Castro GM, et al. The rising function of neutrophil extracellular traps in extreme acute respiratory syndrome coronavirus 2 (COVID-19). Sci Rep. 2020;10:19630.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Karki R, Lee S, Mall R, Pandian N, Wang Y, Sharma BR, et al. ZBP1-dependent inflammatory cell demise, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy throughout coronavirus an infection. Sci Immunol. 2022;7:eabo6294.

    Article 
    CAS 

    Google Scholar
     

  • Rendeiro AF, Ravichandran H, Bram Y, Chandar V, Kim J, Meydan C, et al. The spatial panorama of lung pathology throughout COVID-19 development. Nature. 2021;593:564–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheon IS, Li C, Son YM, Goplen NP, Wu Y, Cassmann T, et al. Immune signatures underlying post-acute COVID-19 lung sequelae. Sci Immunol. 2021;6:eabk1741.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gonçalves JJ, da Mata CP, Lourenço AA, Ribeiro ÁL, Ferreira GM, Fraga-Silva TF, et al. Timeline kinetics of systemic and airway immune mediator storm for complete evaluation of illness consequence in critically in poor health COVID-19 sufferers. Entrance Immunol. 2022;13:903903.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Truffaut L, Demey L, Bruyneel AV, Roman A, Alard S, De Vos N, et al. Publish-discharge important COVID-19 lung operate associated to severity of radiologic lung involvement at admission. Respir Res. 2021;22:1–6.

    Article 

    Google Scholar
     

  • Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, et al. A molecular single-cell lung atlas of deadly COVID-19. Nature. 2021;595:114–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, et al. SARS-CoV-2 an infection paralyzes cytotoxic and metabolic capabilities of the immune cells. Heliyon. 2021;7:e07147.

  • Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021;184:861–80.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Onofrio L, Caraglia M, Facchini G, Margherita V, Placido SD, Buonerba C. Toll-like receptors and COVID-19: a two-faced story with an thrilling ending. Future Sci OA. 2020;6:FSO605.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Patra R, Das NC, Mukherjee S. Focusing on human TLRs to fight COVID‐19: an answer? J Med Virol. 2021;93:615.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Merad M, Martin JC. Pathological irritation in sufferers with COVID-19: a key function for monocytes and macrophages. Nat Rev Immunol. 2020;20:355–62.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mancini I, Baronciani L, Artoni A, Colpani P, Biganzoli M, Cozzi G, et al. The ADAMTS13‐von Willebrand issue axis in COVID‐19 sufferers. J Thromb Haemost. 2021;19:513–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hojyo S, Uchida M, Tanaka Okay, Hasebe R, Tanaka Y, Murakami M, et al. How COVID-19 induces cytokine storm with excessive mortality. Inflamm Regen. 2020;40:1–7.

    Article 

    Google Scholar
     

  • Tan C, Li S, Liang Y, Chen M, Liu J. SARS-CoV-2 viremia might predict speedy deterioration of COVID-19 sufferers. Braz J Infect Dis. 2021;24:565–9.

    Article 

    Google Scholar
     

  • Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, et al. Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 post-mortem expertise. Mod Pathol. 2021;34:1456–67.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, et al. Impaired sort I interferon exercise and inflammatory responses in extreme COVID-19 sufferers. Science. 2020;369:718–24.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, et al. Profiling serum cytokines in COVID-19 sufferers reveals IL-6 and IL-10 are illness severity predictors. Emerg Microbes Infect. 2020;9:1123–30.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Medical options of sufferers contaminated with 2019 novel coronavirus in Wuhan, China. lancet. 2020;395:497–506.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Okay, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Medical traits of novel coronavirus instances in tertiary hospitals in Hubei Province. Chin Med J. 2020;133:1025–31.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Azarkish M, Laleh Far V, Eslami M, Mollazadeh R. Transient full coronary heart block in a affected person with important COVID-19. Eur Coronary heart J. 2020;41:2131.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen G, Wu DI, Guo W, Cao Y, Huang D, Wang H, et al. Medical and immunological options of extreme and reasonable coronavirus illness 2019. J Clin Investig. 2020;130:2620–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pons S, Arnaud M, Loiselle M, Arrii E, Azoulay E, Zafrani L. Immune penalties of endothelial cells’ activation and dysfunction throughout sepsis. Crit Care Clin. 2020;36:401–13.

    Article 
    PubMed 

    Google Scholar
     

  • Yao XH, Luo T, Shi Y, He ZC, Tang R, Zhang PP, et al. A cohort post-mortem examine defines COVID-19 systemic pathogenesis. Cell Res. 2021;31:836–46.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nobari NN, Montazer F, Seirafianpour F, Nikkhah F, Aryanian Z, Goodarzi A. Histopathologic modifications and mobile occasions of organs techniques in COVID-19. J Cell Mol Anesth. 2021;6:81–8.


    Google Scholar
     

  • Shah MD, Sumeh AS, Sheraz M, Kavitha MS, Maran BA, Rodrigues KF. A mini-review on the influence of COVID 19 on important organs. Biomed Pharmacother. 2021;143:112158.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stein SR, Ramelli SC, Grazioli A, Chung JY, Singh M, Yinda CK, et al. SARS-CoV-2 an infection and persistence within the human physique and mind at post-mortem. Nature. 2022;612:758–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stafstrom CE. Neurological results of COVID‐19 in infants and kids. Dev Med Little one Neurol. 2022;64:818–29.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Crunfli F, Carregari VC, Veras FP, Silva LS, Nogueira MH, Antunes AS, et al. Morphological, mobile, and molecular foundation of mind an infection in COVID-19 sufferers. Proc Natl Acad Sci USA. 2022;119:e2200960119.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang L, Zhou L, Bao L, Liu J, Zhu H, Lv Q, et al. SARS-CoV-2 crosses the blood–mind barrier accompanied with basement membrane disruption with out tight junctions alteration. Sig Transduct Goal Ther. 2021;6:337.

    Article 
    CAS 

    Google Scholar
     

  • Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, et al. Intestinal host response to SARS-CoV-2 an infection and COVID-19 outcomes in sufferers with gastrointestinal signs. Gastroenterology. 2021;160:2435–50.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nalbandian A, Sehgal Okay, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Publish-acute COVID-19 syndrome. Nat Med. 2021;27:601–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Criminal H, Raza S, Nowell J, Younger M, Edison P Lengthy covid—mechanisms, danger components, and administration. BMJ. 2021;374:n1648.

  • de Melo GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F, et al. COVID-19–associated anosmia is related to viral persistence and irritation in human olfactory epithelium and mind an infection in hamsters. Sci Transl Med. 2021;13:eabf8396.

    Article 
    PubMed 

    Google Scholar
     

  • Pretorius E, Venter C, Laubscher GJ, Kotze MJ, Oladejo SO, Watson LR, et al. Prevalence of signs, comorbidities, fibrin amyloid microclots and platelet pathology in people with Lengthy COVID/Publish-Acute Sequelae of COVID-19 (PASC). Cardiovasc Diabetol. 2022;21:148.

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Castanares-Zapatero D, Chalon P, Kohn L, Dauvrin M, Detollenaere J, Maertens de Noordhout C, et al. Pathophysiology and mechanism of lengthy COVID: a complete overview. Ann Med. 2022;54:1473–87.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vaira LA, Hopkins C, Sandison A, Manca A, Machouchas N, Turilli D, et al. Olfactory epithelium histopathological findings in long-term coronavirus illness 2019 associated anosmia. J Laryngol Otol. 2020;134:1123–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, et al. 18F-FDG mind PET hypometabolism in sufferers with lengthy COVID. Eur J Nucl Med Mol Imaging. 2021;48:2823–33.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wooden E, Corridor KH, Tate W. Function of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/persistent fatigue syndrome: a potential strategy to SARS-CoV-2 ‘long-haulers’? Continual Dis Transl Med. 2021;7:14–26.

    PubMed 

    Google Scholar
     

  • Korompoki E, Gavriatopoulou M, Hicklen RS, Ntanasis-Stathopoulos I, Kastritis E, Fotiou D, et al. Epidemiology and organ particular sequelae of post-acute COVID19: a story overview. J Infect. 2021;83:1–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Phetsouphanh C, Darley DR, Wilson DB, Howe A, Munier CM, Patel SK, et al. Immunological dysfunction persists for 8 months following preliminary mild-to-moderate SARS-CoV-2 an infection. Nat Immunol. 2022;23:210–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

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