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Comparative study of neutralizing antibodies titers in response to different types of COVID-19 vaccines among a group of egyptian healthcare workers – Virology Journal

  • Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020;27(2):taaa011. https://doi.org/10.1093/jtm/taaa011.

    Article 
    PubMed 

    Google Scholar
     

  • Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Biomed. 2020;91(1):157–60. https://doi.org/10.23750/abm.v91i1.9397.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gupta SL, Jaiswal RK. Neutralizing antibody: a savior in the Covid-19 disease. Mol Biol Rep. 2022;49:2465–74. https://doi.org/10.1007/s11033-021-07020-6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • World Health Organization. WHO Coronavirus (COVID-19) Dashboard 2023. Cited 2023. Available from: https://covid19.who.int/. Accessed Sept 2023./vaccines?m49=818&n=c. Accessed March 18, 2024

  • Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17(1):11–30. https://doi.org/10.1038/s41574-020-00435-4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Deng J, Ma Y, Liu Q, Du M, Liu M, Liu J. Severity and outcomes of SARS-CoV-2 reinfection compared with primary infection: a systematic review and meta-analysis. Int J Environ Res Public Health. 2023;20:3335. https://doi.org/10.3390/ijerph20043335.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sinclair AH, Taylor MK, Weitz JS, Beckett SJ, Samanez-Larkin GR. Reasons for receiving or not receiving bivalent COVID-19 booster vaccinations among adults-United States, november 1-december 10, 2022. MMWR Morb Mortal Wkly Rep. 2023;72(3):73–5. https://doi.org/10.15585/mmwr.mm7203a5.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hodgson SH, Mansatta K, Mallett G, Harris V, Emary KRW, Pollard AJ. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect Dis. 2021;21(2):e26–35. https://doi.org/10.1016/S1473-3099(20)30773-8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fang E, Liu X, Li M, et al. Advances in COVID-19 mRNA vaccine development. Signal Transduct Target Ther. 2022;7(1):94. https://doi.org/10.1038/s41392-022-00950-y.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Excler JL, Saville M, Privor-Dumm L, et al. Factors, enablers and challenges for COVID-19 vaccine development. BMJ Glob Health. 2023;8:e011879. https://doi.org/10.1136/bmjgh-2023-011879.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lopez Bernal J, Andrews N, Gower C, Gallagher E, Simmons R, Thelwall S, Stowe J, Tessier E, Groves N, Dabrera G, Myers R, Campbell CNJ, Amirthalingam G, Edmunds M, Zambon M, Brown KE, Hopkins S, Chand M, Ramsay M. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med. 2021;385:585–94.

    Article 
    PubMed 

    Google Scholar
     

  • Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383:2603–15. https://doi.org/10.1056/NEJMoa2034577.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zheng J, Deng Y, Zhao Z, et al. Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects. Cell Mol Immunol. 2022;19(2):150–7. https://doi.org/10.1038/s41423-021-00774-w.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gudbjartsson DF, Norddahl GL, Melsted P, et al. Humoral immune response to SARS-CoV-2 in iceland. N Engl J Med. 2020;383(18):1724–34. https://doi.org/10.1056/NEJMoa2026116.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Favresse J, Gillot C, Di Chiaro L, et al. Neutralizing antibodies in COVID-19 patients and vaccine recipients after two doses of BNT162b2. Viruses. 2021;13(7):1364. https://doi.org/10.3390/v13071364.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cromer D, Steain M, Reynaldi A, Schlub TE, Wheatley AK, Juno JA, Kent SJ, Triccas JA, Khoury DS, Davenport MP. Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis. Lancet Microbe. 2022;3:e52-61. https://doi.org/10.1016/S2666-5247(21)00267-6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gilbert PB, Montefiori DC, McDermott AB, Fong Y, Benkeser D, Deng W, Zhou H, Houchens CR, Martins K, Jayashankar L, et al. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial. Science. 2022;375:43–50. https://doi.org/10.1126/science.abm3425.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hernández AF, Calina D, Poulas K, Docea AO, Tsatsakis AM. Safety of COVID-19 vaccines administered in the EU: should we be concerned? Toxicol Rep. 2021;8:871–9. https://doi.org/10.1016/j.toxrep.2021.04.003.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Saker K, Pozzetto B, Escuret V, et al. Evaluation of commercial Anti-SARS-CoV-2 neutralizing antibody assays in seropositive subjects. J Clin Virol. 2022;152:105169. https://doi.org/10.1016/j.jcv.2022.105169.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Perera RAPM, Ko R, Tsang OTY, et al. Evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in human, canine, cat, and hamster sera. J Clin Microbiol. 2021;59(2):e02504-20. https://doi.org/10.1128/JCM.02504-20.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Morales-Núñez J, Muñoz-Valle J, Meza-López C, Wang L, Sulbarán A, Torres-Hernández P, Bedolla-Barajas M, et al. Neutralizing antibodies titers and side effects in response to BNT162b2 vaccine in healthcare workers with and without prior SARS-CoV-2 infection. Vaccines. 2021;9(742):1–13.


    Google Scholar
     

  • Taylor SC, Hurst B, Charlton CL, et al. A new SARS-CoV-2 dual-purpose serology test: highly accurate infection tracing and neutralizing antibody response detection. J Clin Microbiol. 2021;59:e02438-20. https://doi.org/10.1128/JCM.02438-20.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garcia-Beltran WF, Lam EC, Astudillo MG, et al. COVID-19-neutralizing antibodies predict disease severity and survival. Cell. 2021;184(2):476-488.e11. https://doi.org/10.1016/j.cell.2020.12.015.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sette A, Crotty S. Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines. Immunol Rev. 2022;310(1):27–46. https://doi.org/10.1111/imr.13089.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Virk A, Johnson MG, Roellinger DL, et al. Hybrid immunity provides protective advantage over vaccination or prior remote coronavirus disease 2019 alone. Open Forum Infect Dis. 2023;10(5):161. https://doi.org/10.1093/ofid/ofad161.

    Article 
    CAS 

    Google Scholar
     

  • León TM, Dorabawila V, Nelson L, et al. COVID-19 cases and hospitalizations by COVID-19 mvaccination status and previous COVID-19 diagnosis—California and New York, May–November 2021. MMWR Morb Mortal Wkly Rep. 2022;71(4):125–31. https://doi.org/10.15585/mmwr.mm7104e1.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17:181–92.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Collier DA, Ferreira IATM, Kotagiri P, et al. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature. 2021;596:417–22. https://doi.org/10.1038/s41586-021-03739-1.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Evans JP, Zeng C, Carlin C, et al. Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection. Sci Transl Med. 2022;14(637):8057. https://doi.org/10.1126/scitranslmed.abn8057.

    Article 
    CAS 

    Google Scholar
     

  • Nanda R, Gupta P, Giri AK, Patel S, Shah S, Mohapatra E. Serological evaluation of antibody titers after vaccination against COVID-19 in 18–44-year-old individuals at a tertiary care center. Cureus. 2023;15(6):e40543. https://doi.org/10.7759/cureus.40543.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med. 2021;27(7):1205–11. https://doi.org/10.1038/s41591-021-01377-8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Adjobimey T, Meyer J, Sollberg L, et al. Comparison of IgA, IgG, and neutralizing antibody responses following immunization with moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm’s COVID-19 vaccines. Front Immunol. 2022;13:917905. https://doi.org/10.3389/fimmu.2022.917905.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van Gils MJ, Lavell A, van der Straten K, et al. Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: a prospective cohort study. PLoS Med. 2022;19(5):e1003991. https://doi.org/10.1371/journal.pmed.1003991.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wei J, Pouwels KB, Stoesser N, et al. Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines. Nat Med. 2022;28:1072–82. https://doi.org/10.1038/s41591-022-01721-6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sahin U, Muik A, Derhovanessian E, et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Nature. 2020;586(7830):594–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Dos Santos WG. Natural history of COVID-19 and current knowledge on treatment therapeutic options. Biomed Pharmacother. 2020;129:110493. https://doi.org/10.1016/j.biopha.2020.110493.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sahin U, Karikó K, Türeci Ö. mRNA-based therapeutics–developing a new class of drugs. Nat Rev Drug Discov. 2014;13(10):759–80.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Earle KA, Ambrosino DM, Fiore-Gartland A, et al. Evidence for antibody as a protective correlate for COVID-19 vaccines. Vaccine. 2021;39:4423–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pouwels KB, Pritchard E, Matthews PC, et al. Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nat Med. 2021;27:2127–35. https://doi.org/10.1038/s41591-021-01548-7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • El Sahly HM, Baden LR, Essink B, et al. Efficacy of the mRNA-1273 SARS-CoV-2 vaccine at completion of blinded phase. N Engl J Med. 2021;385(19):1774–85. https://doi.org/10.1056/NEJMoa2113017.

    Article 
    PubMed 

    Google Scholar
     

  • Wang Z, Muecksch F, Schaefer-Babajew D, et al. Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection. Nature. 2021;595:426–31. https://doi.org/10.1038/s41586-021-03696-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Muecksch F, Wang Z, Cho A, et al. (2022) Increased potency and breadth of SARS-CoV-2 neutralizing antibodies after a third mRNA vaccine dose. BioRxiv. 2022;02:14.480394. https://doi.org/10.1101/2022.02.14.480394.

    Article 
    CAS 

    Google Scholar
     

  • Goel RR, Painter MM, Apostolidis SA, et al. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021;374(6572):abm0829. https://doi.org/10.1126/science.abm0829.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chia WN, Zhu F, Ong SWX, et al. Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study. Lancet Microbe. 2021;2(6):e240-9. https://doi.org/10.1016/S2666-5247(21)00025-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ebinger JE, Fert-Bober J, Printsev I, Wu M, Sun N, Prostko JC, Frias EC, Stewart JL, Van Eyk JE, Braun JG, et al. Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2. Nat Med. 2021;27:981–4.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

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