Extreme Flu Confers Greater Threat for Neuro Problems vs COVID

TOPLINE:

Hospitalization for influenza is linked to a better danger for subsequent neurologic problems together with migraine, stroke, or epilepsy than hospitalization for COVID-19, outcomes of a big research present.

METHODOLOGY:

• Researchers used healthcare claims information to check 77,300 individuals hospitalized with COVID-19 with 77,300 hospitalized with influenza. The research didn’t embody people with lengthy COVID.
• Within the closing pattern of 154,500 contributors, the imply age was 51 years, and greater than half (58%) have been feminine.
• Investigators adopted contributors from each cohorts for a 12 months to learn how lots of them had medical look after six of the commonest neurologic problems: Migraine, epilepsy, stroke, neuropathy, motion problems, and dementia.
• If contributors had one in all these neurologic problems previous to the unique hospitalization, the first final result concerned subsequent healthcare encounters for the neurologic analysis.

TAKEAWAY:

• Individuals hospitalized with COVID-19 vs influenza have been considerably much less more likely to require care within the following 12 months for migraine (2% vs 3.2%), epilepsy (1.6% vs 2.1%), neuropathy (1.9% vs 3.6%), motion problems (1.5% vs 2.5%), stroke (2% vs 2.4%), and dementia (2% vs 2.3%) (all P < .001).
• After adjusting for age, intercourse, and different well being situations, researchers discovered that folks hospitalized with COVID-19 had a 35% decrease danger of receiving look after migraine, a 22% decrease danger of receiving look after epilepsy, and a 44% decrease danger of receiving look after neuropathy than these with influenza. Additionally they had a 36% decrease danger of receiving look after motion problems, a ten% decrease danger for stroke (all P < .001), in addition to a 7% decrease danger for dementia (P = .0007).
• In contributors who didn’t have a preexisting neurologic situation on the time of hospitalization for both COVID-19 or influenza, 2.8% hospitalized with COVID-19 developed one within the subsequent 12 months in contrast with 5% of these hospitalized with influenza.

IN PRACTICE:

“Whereas the outcomes weren’t what we anticipated to seek out, they’re reassuring in that we discovered being hospitalized with COVID didn’t result in extra look after frequent neurologic situations when in comparison with being hospitalized with influenza,” research investigator Brian C. Callaghan, MD, of College of Michigan, Ann Arbor, Michigan, stated in a press launch.

SOURCE:

Adam de Havenon, MD, of Yale College in New Haven, Connecticut, led the research, which was printed on-line on March 20 in Neurology.

LIMITATIONS:

The research relied on ICD codes in well being claims databases, which might introduce misclassification bias. Additionally, by deciding on solely people who had related hospital-based care, there could have been a range bias primarily based on illness severity.

DISCLOSURES:

The research was funded by the American Academy of Neurology. De Havenon reported receiving marketing consultant charges from Integra and Novo Nordisk and royalty charges from UpToDate and has fairness in TitinKM and Certus. Callaghan consulted for DynaMed and performs medical authorized consultations together with consultations for the Vaccine Harm Compensation Program. Different disclosures have been famous within the authentic article.